From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9

(Cell Chemical Biology 26, 32–40, January 16, 2020) In the originally published version of this article, following reference describing first synthesis compound 1 is missing. This error has now been corrected online. The authors apologize for omission. Venkov, A.P., and Angelov, P.A. (2003). 1,1-disubstituted tetrahydroisoquinolines from enaminones via Pictet–Spengler reaction. Synth. Commun. 33, 3025–3033. From Screening to Targeted Degradation: Strategies Discovery Optimization Small Molecule Ligands PCSK9Petrilli et al.Cell BiologyOctober 22, 2019In BriefPetrilli al. describe identification high-affinity small-molecule binders PCSK9 through two complementary hit-to-lead approaches. lead was shown bind in a cellular thermal shift assay subsequently developed into targeted protein degrader. Full-Text PDF Open Archive